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The authors demonstrated that the surface-induced formation of carbonateapatite started from aggregation of pre-nucleation clusters of yet unknown CaPO4 leading to nucleation of ACP before further development of oriented apatite crystals.
It is important that the new candidate biomarkers be evaluated in TB-endemic countries before further development is considered.
In vitro toxicity screening is a compulsory aspect of the pilot safety assessment of plant extracts and compounds before further development and commercialisation [ 31].
Due to its size, howeer, the essential parts of 7 should be determined in a structure-activity study before further development.
An improved formulation for RG13022 is therefore required before further development of this or other similar protein tyrosine kinase inhibitors can be made.
From an environmental health perspective, retinal light injury and the potential risks for chronic exposure from using LEDs as a domestic light source require assessment before further development of this important, energy-saving technology.
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With illegal and irresponsible agriculture also an issue, the race is on to put RTRS guidelines into place before any further development continues.
Throughout the UK, community activists will no doubt continue to demand that politicians, developers and the whole planning system be forced to commit to working with local people before any further development is authorised.
In case of preclinical animal tests, which are usually performed in mouse or rat, the most potent inhibitory compounds would have been sorted out before entering further development for human application.
These 6 researchers' propositions were sent to all participants for agreement before any further development.
In view of the limited evidence of the effectiveness of this programme, we recommend to conduct a cost/benefit analysis before undertaking further development.
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