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Participants avoided exercise (apart from that performed in our laboratory) for 24 h before inserting the sensor (48 h before each study exercise session) as well as during the 3 days of sensor wear.
Continuous glucose monitoring was established 24 48 h before each study visit by inserting a single subcutaneous glucose sensor (SEVEN PLUS; Dexcom, Inc; San Diego, CA) into the subcutaneous tissue of the abdomen.
A FreeStyle Navigator sensor (Abbott Diabetes Care, Alameda, CA) was inserted the day before each study.
The macaques were fasted overnight before each study.
Two reviewers worked independently on each study, before reaching consensus.
Genomic control was applied to each study before meta-analysis.
Written consent was sought from each study participants before interview.
At the end of each study, coned-down oblique X-ray images of the sensor sites were taken to measure the actual distance between the tips of the glucose sensors.
Food and fluids consumed by participants during each study period were weighed before and after each meal.
Before the interviews, approval was obtained from each study hospital.
Participants in the Sensor Off arm wore the device for 2 weeks prior to each study visit.
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