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Randomized clinical trials in patients without symptoms must be completed before conclusions are made.
A brief discussion on the hierarchical LCD framework and the future works is presented before conclusions are made.
Replication of these findings is needed before conclusions are made.
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Before any conclusions are made, any assumptions and uncertainties will be tested using sensitivity analysis.
These indications must now be assessed in a larger patient material before final conclusions are made.
In this regard, if ALDH+/CD34- cell subset may also contain a very rare, primitive stem cell remains to be demonstrated and it is conceivable that a specific marker for the selection of human CD34-negative stem cells needs to be identified before definite conclusions are made, as suggested by other research groups [ 9, 17, 18].
Only correlations with adjusted p-value ≤ 0.05 were considered significant, however biological conclusions that rely on p-values, especially so close to the arbitrary cut-off of significance, should be interpreted with caution and the actual effect size should also be carefully examined before definitive conclusions are made.
A second group of strains isolated from 1995 to 2003 appear to form a different cluster, but more data is still needed before any conclusions are made about the strength of this association since the bootstrap values here are rather weak.
Therefore, any hypotheses of historic migration suggested by LAPSTRUCT would require additional evidence before a conclusion is made.
In the Discussion section, the results are further discussed and compared with other well studied researches like the area restricted search, before the Conclusion is made.
It is our speculation that genotype J/clade 2 might be predominant in China, although studies involving strains from more places in China will be necessary before the conclusion is made.
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