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Before commencement of study an inter rater exercise assessing the doctors on the instrument was conducted revealed a simple percentage agreement of about 93% for all diagnosable conditions on K-SADS.
Additionally, those with missing case notes, or whose DST was not confirmatory of MDR-TB, earlier treatment dates before commencement of study, who died within 24 h of commencement of MDR-TB treatment and XDR-TB patients were also excluded from the study.
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Radiographs are taken before commencement of the study and at the end of the study.
They received a written information sheet followed by a check list before commencement of the study to ensure their understanding of the principal study concepts.
The study was approved by the LUTH research and ethics committee before commencement of the study.
The study was approved by the human research ethics committee at Austin Health, and all participants gave informed consent before commencement of the study.
It was agreed before commencement of the study that a person who would accept to be interviewed after explanations would have consented to participate in the study.
Animals were kept for 5 days to allow for acclimatization to the laboratory conditions before commencement of the study.
The institution's ethical approval was obtained before commencement of the study, and all randomized patients gave informed consent.
Ethical approval was received before commencement of the study from the North of Scotland Local Research Ethics Committee and informed consent was received from every patient prior to participation in the study, which was performed in accordance with the ethical standards of the 1964 Declaration of Helsinki, as revised in 2000.
All subjects gave informed consent before commencement of the study.
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