Sentence examples for before clinical implementation of from inspiring English sources

Before clinical implementation of CBM-I are considered, future studies need to follow up these group differences, perhaps in the first instance 24 h later [ 31].

However, before clinical implementation of MR-HIFU for liver tumour ablation is feasible, several organ-specific challenges have to be addressed.

Before clinical implementation, blocking of distinct pro-apoptotic pathways needs further research and understanding.

Before the clinical implementation of SWI, susceptibility imaging relied only on GE sequences.

We derive testable predictions for different experimental settings that are suggested before the clinical implementation of the combination treatment.

We will further discuss these results and suggest critical experiments that need to be carried out before a clinical implementation of the combination treatment.

All the above underscore the need for caution before the clinical implementation of molecular assays for decision making about extended endocrine therapy and call for in-depth investigation of their prognostic and predictive value.

Summarising our findings, we argue that before a clinical implementation of a combination therapy it is necessary to experimentally verify whether (1) IFN α leads to a similar activation of human HSCs as in mice, (2) CML stem cells are also activated by IFN α and (3) how this activation changes under the additional administration of a TKI.

One of the objectives to be addressed before clinical implementation is intra-patient variation of the molecular signature when applied to multiple tumours from the same patient.

During the last decade, cross-validation methods have been used widely for everything from robust variable selection in gene expression array studies [ 41] to reducing false positives in gene-gene interaction studies [ 42, 43] to evaluating the predictive accuracy of molecular or genetic classifiers of disease before clinical implementation [ 44].

Therefore, the predictive value of ANXA10 needs to be validated in prospective studies before clinical implementation both to verify the predictive value of ANXA10 and to determine the optimal cutoff values.