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The conclusion of the Chinese study was that there are still significant technical challenges to be solved before clinical application of Crispr for editing embryos is possible.
However, before clinical application of BTX-A for TN treatment can become routine, a standardized therapeutic regimen should be established.
Residents of neurosurgery need many years to develop microneurosurgical skills, and laboratory training models are essential for developing and refining surgical skills before clinical application of microneurosurgery.
Several hurdles that have to be overcome before clinical application of engineered heart tissue might become a realistic scenario are also addressed.
Our studies not only pave a way to the understanding of pharmacological mechanisms of Gefitinib, but also implicate for the necessity to prescreen p53 expression level before clinical application of Gefitinib in human cancer therapy.
These studies demonstrated the need for further functional comparison between hES and iPS-derived cells to evaluate their similarities and differences before clinical application of these cell types.
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However, before clinical application and transplantation of MSC-derived cells in scaffolds, the safety and efficiency, but also possible interference in differentiation due to the material must be preclinically tested.
The SNP array method had been validated before clinical application and small numbers of cells from hESC lines were used, which was described in the report [ 24]. qPCR was used to validate the results of NGS and SNP array.
Before the clinical application of insulin, diabetes was a feared disease that commonly led to death.
Further studies are needed before a clinical application of MenSCs-induced IVM is considered.
Indeed, there is still some uncertainty on the safety of these cells [18] and further pre-clinical validation is necessary before the clinical application of stem cell therapy.
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