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Perturbations to mammalian switch/sucrose non-fermentable (mSWI/SNF) chromatin remodeling complexes have been widely implicated as driving events in cancer1.
The genetic variants of the factor V (G1691A), prothrombin (G20210A) and MTHFR (C677T) genes have been widely implicated as inherited risk factors for developing venous thrombosis.
Dopamine has been widely implicated as the central mechanism through which drugs of abuse produce their effects [31].
Recently, proton pump inhibitors (PPIs) have been widely implicated as a significant risk factor for hospital-acquired CDI [ 3- 9].
Free radical metabolites have been widely implicated as contributing to disease states and may be involved in MEU carcinogenicity in extrahepatic tissues.
Wnt/β-catenin signaling pathway has been widely implicated as the regulator of cell invasion and migration in cancers [ 40, 41].
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Heat shock proteins are widely implicated as playing roles in insect diapause [54], [63], [64], [65], [66], as are hexamerins [54], [67], [68] and several genes in the insulin pathway [69], [70], [71].
Further, it is widely implicated as an important cofactor for HIV acquisition [ 4, 5].
They have been widely implicated to function as major contenders in cancer progression, frequently due to their role in invasion, proliferation and metastasis.
Of these, human SEPT9 has been widely implicated in cancers of epithelial origin, including breast cancer, as well as leukemia.
In plants, small RNAs have been widely implicated in varied developmental events and as guide RNAs in many gene silencing pathways [ 1- 6].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com