Early accurate diagnosis, if possible assisted by genetic confirmation of mutation is important, since IL-1-blocking agents have been very efficacious in patients with MWS [ 16, 21, 25] and early therapeutic intervention is necessary to prevent irreversible organ damage and, in particular, hearing loss [ 12, 13, 17].
NE reuptake blockers have been shown to be very efficacious in treating ADHD symptoms, although their cardiac side effects have limited clinical utility in children [ 47, 62].
Although it has been shown that Nutlin alone is very efficacious in MDM2 Ampl sarcoma cell lines in vitro and in vivo [ 11, 20], the effects of combinations with standard therapeutics in sarcomas is still unknown.
In a recent review of 344 dogs undergoing antiepileptic treatment of any kind in a referral clinic, only 14%% became seizure free [ 26], indicating that imepitoin is very efficacious in responsive patients.
NADPH oxidase-activating substances such as phytol (3,7,11,15-tetramethyl-2-hexadecene-1-ol), were identified from studies performed on a human neutrophil cell line, and have subsequently been shown to be very efficacious in the treatment of arthritis in rats [ 20].
School-based delivery of injections has proven to be very efficacious in New Zealand [ 25], but is a limited option in our setting due to low school attendance, recognised challenges in the implementation of school-based health programs in remote communities, and the requirement for ongoing prophylaxis for many people after school-leaving age.
Using this in vitro approach, we demonstrate that although the combination cisplatin-paclitaxel used at high doses is very efficacious in killing a large proportion of ovarian cancer cells encompassing broad genetic backgrounds, there are cells that escape the therapy and repopulate the culture following an otherwise apparent successful chemotherapeutic round.
It might sound a tad radical but throwing your make-up pencil sharpener in the dishwasher or washing by hand can also be very efficacious in removing bacteria.
Goal-directed hemodynamic management is very efficacious early in the course of severe sepsis and septic shock [ 16], but ineffective if delayed [ 17].
Although the smallpox vaccines used during the smallpox eradication campaign (now called first-generation vaccines) were very efficacious, they were typically propagated in the skin of calves under conditions that did not adhere to good manufacturing practices (GMP).
