Sentence examples for been validated to target from inspiring English sources

Further supporting this conclusion is the fact that several of the DE miRNAs in our study have been validated to target genes in these pathways in other species.

The scVEGF-based family of probes has been validated to target the VEGF receptor in vitro and in vivo tumor angiogenesis [ 90, 91].

miR-143 has been validated to target the oncogene KRAS [ 42] and may also modulate extracellular-regulated protein kinase 5 (ERK5) [ 43, 44] and bcl-2 [ 30].

The differential expression of three miRNAs, miR-9*, miR-145 and miR-126, which have previously been validated to target SOX2, suggests the possible existence of novel autoregulatory loops between SOX2 and miRNAs it directly or indirectly regulates.

Third, miR857 was validated to target the LAC7 (Atranscripttranscript, which encodes a laccase family protein with predicted multicopper oxidase function.

Interestingly, miR447a and miR856 were validated to target transcripts in gene families distinct from those similar to the foldback sequences (Figure 1B, Table 2; [34]).

Interestingly, Csi-miR164 was highly expressed in fruit ripening stage, and was validated to target a NAC transcription factor.

The mir-19a and mir-19b, which are both expressed from the oncogenic mir-17-92 mir-17-92 mir-17-92ated to target the MYclusterR in the luciferase reporter assay system in HEK293 cells.

Since miR-29 family was validated to target Dnmt3a and Dnmt3b [ 30], the expression profile of the miR-29 family was evaluated and showed that miR-29a did not contribute to the phenotype of the malignant cells, as there were no statistically significant differences observed between the 3 studied cell lines).

Of important note, genes exhibiting the similar expression patterns to CDKN1C include KRT17, KRT5 and LAMB3 that have been validated to be EZH2 target in our previous study [23].

miR-124 may be a potential regulator of the endocytosis function of HL-60 acting through its validated target LDLRAP1 encoding low density lipoprotein receptor adaptor protein 1 [38] and putative target EPN2 encoding epsin 2. miR-503 has been experimentally validated to target CCND1 encoding cyclin D1 [39], which is involved in responses to inorganic substances.