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The 70-gene signature has been validated in subsequent works and now undergoes a large scale prospective clinical trial [ 1].
Although the data are not from a nested case-control study and have not been validated in subsequent studies, they are useful for illustration.
Some studies have generated preliminary gene signatures with potential predictive value for docetaxel and paclitaxel plus FAC [70,71] but these signatures have not yet been validated in subsequent studies and are not ready for use in clinical practice.
Both retrospective reports have been validated in subsequent studies (Edwards et al, 2000; Fennell et al, 2005), although only one validation was in consecutive presenting patients rather than a clinical trial population (Edwards et al, 2000).
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From a dense random path, the path seems more random and may help improve the surface texture, which will be validated in subsequent analysis.
Responses were validated in subsequent interviews with other stakeholders.
Thus, our findings should be validated in subsequent prospective studies in future before clinical application.
Consequently, the results obtained in this study need to be validated in subsequent studies, in which clusters are tested in a pre hoc fashion.
This would ensure data synthesis and integration (as in this review) in order to narrow down replicated biomarkers which can be then be validated in subsequent hypothesis-driven research.
Findings from large registries often result in interesting hypotheses, which in turn need to be validated in subsequent studies because of the lack of systematic collection of recipient serum and cell samples, and/or prospective outcome data [ 26].
If this finding is validated in subsequent genetic and molecular studies, it would suggest that TDP-43 plays a role in the modulation of synaptic homeostasis via the dpp /BMP signaling cascade.
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