In addition, some methods have been shown to predict health outcomes; for example, monofilament examination has shown significant predictive power in identifying individuals with neuropathy due to diabetes and leprosy who are at greatest risk of experiencing foot ulcerations.[6], [17] However, these techniques must be validated in resource-constrained settings to ensure feasibility and accuracy.
Although, the instruments we used have been validated in some resource-limited countries (Kotze et al., 2013; Lipps et al., 2010), consideration should be given to validating them in the country of study prior to their use.
ICU mortality prediction models provide robust tools for research and benchmarking in the developed world, but an ICU mortality prediction model has not been validated in a resource-poor setting.
While daily home collection of mucosal samples for herpesvirus culture and PCR has been validated in multiple studies in resource-rich settings, [11], [12], [20], [21], [22], [23], to our knowledge this is the first study to perform intensive mucosal sampling in a resource-limited setting.
This questionnaire has been validated in general medical and surgical patients and had been shown to correlate with subsequent health status and resource utilisation [ 8].
Although there is no indication that our rules would perform differently in resource-poor settings, they should be validated in populations differing from Swiss HIV patients.
This hypothesis remains to be validated in the future.
The methodology will be validated in selected patient populations.
They'll need to be validated in clinical trials.
These findings are being validated in an ongoing, prospective study.
