85 87 While they will have to be validated in peripheral SpA, they can be assumed useful for clinical practice until proven otherwise.
The primary efficacy end point, the PSpARC40, has not been validated in other peripheral SpA cohorts.
To date, the only tool that has been validated in neuropathic pain syndromes of both central and peripheral origins is the Neuropathic Pain Symptom Inventory (NPSI).
Peripheral neuropathy was assessed using the 15-item Michigan Neuropathy Screening Instrument, which has been validated in previous studies (18); the self-reported presence of ≥6 symptoms (e.g., numbing, burning, or soreness) was coded as neuropathy.
The testing machine had been validated in our laboratory, as recommended by Turner and Burr [ 13], using plastics material standards, and had been used previously to assess the compressive strength of peripheral bone specimens [ 14].
The Portsmouth predictor equation (P POSSUM) was highly predictive of mortality in a study of elective craniotomies for neurosurgery but has yet to be validated in spinal, peripheral nerve or acute cranial neurosurgery.
CD4+ T cell epitopes thus identified were validated in the human system by stimulation of peripheral blood mononuclear cells (PBMC) from healthy donors and melanoma patients.
In Japan, duloxetine has been approved for treatment of major depressive disorder and diabetic peripheral neuropathic pain after its efficacy for these conditions was validated in phase III studies [ 23, 24].
I was validated in what I was experiencing.
Herein, we report that peripheral blood mononuclear cells from patients with severe S. aureus infections demonstrate a distinctive and robust gene expression profile which is validated in a distinct group of patients and on a different microarray platform.
