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Subsequently, these signatures have been validated in larger cohorts [ 3, 4], the datasets were re-analyzed to assess their robustness [ 5], or other data mining techniques were tested [ 6, 7].
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Although these new criteria have been validated in large databases, much controversy still surrounds them.
This method has been validated in large animal models of myocardial infarction and can be used to serially measure infarct size in the same individuals.
The WHO released a standardized guide for the use of ultrasonography in schistosomiasis that has been validated in large-scale studies [6, 7].
Meanwhile, most of the works have not been validated in large scale, leading to unconvincing results.
The clinical value of AFC-assisted TURBT has been validated in large prospective randomized clinical trials.
All versions have been validated in large samples in different cities within three countries (Los Angeles, Helsinki, Porto) [ 18].
But it should also be considered that no possible biomarker has been validated in large cohort studies until now [ 81].
Corresponding levels for critically ill patients may well be higher, but have never been validated in large studies.
However, to our knowledge, these clinically relevant findings have been not yet been validated in large experiences from other centers.
The list of candidate biomarkers proposed for gastric cancer is steadily increasing (Polanski and Anderson, 2007), although to date few have been validated in large patient cohorts.
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