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The IPAT tool has been validated in critically ill patients as a screening tool to detect acute distress in critical care patients once they are awake, alert & orientated, with a cut off ≥7 / 20 indicating morbidity [5].
MPAP can be estimated as the sum of echocardiographically derived mean right ventricular to right atrial systolic pressure gradient and right atrial pressure; however, this has not been validated in critically ill patients.
At present, the most widely used classification is the RIFLE an acronym for Risk, Injury, Failure, Loss, and End-stage renal disease system, which was initially proposed by the Acute Dialysis Quality Initiative group [7] and has been validated in critically ill adult patients [8].
It has been validated in critically ill patients [ 32, 33 ].
However, this approach has never been validated in critically ill patients.
The estimating equations used in this study, have not been validated in critically ill patients with early AKI.
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In the early 2000s, dynamic variables were validated in critically ill patients ventilated with high VT (>8 mL/kg−1 of IBW) [ 1, 8, 9, 43, 44].
Seymour and colleagues [ 15] have found a good correlation between quadriceps cross-sectional area and strength, but this needs to be validated in critically ill patients.
The Functional Comorbidity Index (FCI) was recently developed to predict physical function based on comorbidity data [ 9] and was validated in critically ill patients with acute lung injury (ALI) [ 10].
The kinetics of 3-OMG absorption have never been validated in the critically ill population.
Furthermore our clinical and laboratory tools for diagnosing sepsis have been developed in different populations and have not been validated in chronic critically ill patients, a population of patients that is expected to increase in future.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com