Sentence examples for been validated in cell from inspiring English sources

The preexistence of EGFR TKI resistant cells have been validated in cell lines as well as in primary human lung tumors through high-throughput FISH analyses and peptide nucleic acid-clamping PCR or ultra-sensitive droplet digital PCR (Turke et al., 2010; Oh et al., 2011; Watanabe et al., 2015).

The potential for PAMAM dendrimers in oral drug delivery has been validated in cell culture models and in animals.

The validity of this strategy is underlined by the fact that several predictions from our study have recently been validated in cell lines.

Wnt-activation was validated in cell lines with over-expression of EWS/WT1 and in DSRCT.

Specificity was validated in cell sections where DKK-1 levels were diminished using siRNA.

None down-regulation of miRNAs in ER+ compared to ER- tumors was validated in cell lines; miR-203 was even significantly up-regulated (p = 0.0226).

In a previous study, we identified signaling pathways required for cell growth, proliferation, and/or survival of HepG2 cells, some of them have been validated in HuH7 cells, using real-time cell proliferation analysis on xCELLigence [ 12].

The Distress-Thermometer has already been validated in stem cell transplantation patients [ 61].

However, these interactions were found in yeast and up to now the binding between Rab proteins and Golgins has not been validated in mammalian cell lines.

Hits have been validated in several cell lines and are now undergoing a medicinal chemistry strategy to ensure a desirable pharmacological profile.

Our ChIP assay using both anti-USF and anti-SREBP antibodies has been validated in this cell type on the FAS promoter [9], making a false negative unlikely.