Sorafenib, a tyrosine kinase inhibitor is validated in advanced hepatocellular carcinoma.
A slightly modified version of the tool (the MVQOLI-M) was validated in advanced AIDS patients in Uganda [ 44].
Gene-based markers were validated in advanced breeding lines derived from the RH-1 parent and also a second RLN tolerance source, RH-2 (M. truncatula ssp. tricycla).
The FACT-ES has been validated in the advanced breast cancer setting, and has been shown to have good internal consistency, reliability, patient acceptability and sensitivity to clinically significant change (Cella, 1997).
Content validity for the symptom scales used has been validated in patients with advanced breast cancer or MBC in a phase 2 study of eribulin (E7389-G000-211; Clidentifierls.gov ideNCT00246090T00246090) [ 36].
A higher score indicates more depression, and the tool has been validated in patients with advanced cancer [ 19].
14 Additionally, FreeSurfer-derived volumes have not been validated in patients with more advanced MRI SVD; however, a radiologist visually inspected all scans and excluded those with visually obvious errors.
Indeed, this approach has been validated in controlled phase III trials in patients with advanced solid tumours (Sandler et al, 2006; Reck et al, 2009).
Bioimpedance cardiography has been validated in some patient groups [ 7], and newer systems with improved software for advanced signal processing may be valid in critically ill patients [ 8].
A recent evaluation of over 1000 patients with advanced oesophagogastric cancer identified several prognostic factors affecting survival outcomes (Chau et al, 2004) (the Royal Marsden Hospital Prognostic Index), which have been validated in a subsequent data set (Chau et al, 2009b).
