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Magnetic resonance imaging (MRI) provides three-dimensional noninvasive quantitative methods of cerebral blood flow (CBF) imaging, but these MRI techniques have not yet been validated for mice.
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Embryonic stem (ES) cells have been available from inbred mice since 1981 but have not been validated for other rodents.
Additionally, other tumor-targeting agents such as Chlorotoxin-Cy5.5 have been validated for optical imaging of malignant cancer cells using various mouse models of cancer.
and used for the tissue distribution and high-fat diet analyses; anti-mouse and anti-rat SIRT3 serum was also developed against the C-terminal regions of each respective protein (Covance), and the anti-mouse serum was validated for specificity using brown fat, cardiac tissue, and soleus muscle from SIRT3 knockout mice (Supplemental Fig. 1), then used for analyzing the exercise samples.
Implications and future directions Candidate anti-cancer drugs identified in organ culture or cell-based screens must be validated for efficacy in preclinical models such as KIC mice.
These assays were validated for placental samples.
The assay was validated for reindeer plasma.
The probe set was validated for consistency.
Quantitative Ho SPECT was validated for clinical application.
123I-2β-carbomethoxy-3β-(4-iodophenyl)tropane 123I-2β-carbomethoxy-3β- 4-iodophenyl tropanet 123I-2β-carbomethoxy-3β- 4-iodophenyl tropanetly induced to model several diseases.
However, such pathways have not been validated in HD mouse models thus far.
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