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However, existing clinical trial settings have the apparent limitation of only identifying drugs with mechanisms of action similar to already approved drugs, while screening out analgesics with completely new mechanisms of action, as these clinical models have usually been validated by demonstrating opioid or NSAID activity.
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The concepts are validated by demonstrating the detection of biotin streptavidin binding and DNA hybridization.
The potential of the developed equipment and the HT-screening concept in general was validated by demonstrating the reproducibility of experimental flux and selectivity data for a lab-made dense Matrimid and a commercial asymmetric membrane at all 16 positions.
The potential of the developed equipment and of the HT-screening concept in general was validated by demonstrating both the reproducibility of experimental flux and selectivity data, and the scalability of these data between the HT-module and a conventional dead-end filtration set-up.
However, the finding was validated by demonstrating a decline in excess strong correlations over the random case with fewer samples (Figure S2, where the ratio in number of coefficients, similar to Figure1B, was plotted).
14 RVI was validated by demonstrating a strong relationship with histological MVI and prediction of MVI in an independent cohort.
The method was validated by demonstrating by PCR the same HPV types in archival smears and corresponding cervical biopsies of cervical cancer patients.
The technique was validated by demonstrating that DNAse treatment of portions of the murine aorta generated enhanced TUNEL signals in EC (Supplemental Fig. 3).
Q-PCR methods were validated by demonstrating increased expression of IL-1β and IL-6 expression in rheumatoid arthritis synovial samples compared with osteoarthritis synovium.
This was validated by demonstrating that suppression of apical sodium bile acid transporter (ASBT), a transporter with significant involvement in cholangiocyte proliferation, has no effect on the inhibitory effects induced by TGR5 agonists on ciliated cholangiocyte proliferation.
The use of the HPPTP assay as a reliable processing procedure was validated by demonstrating a complete agreement in HPV detection and 93% agreement in HPV typing between 39 archival Pap-stained and paired fresh-frozen cervical smears.
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