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Furthermore, transcriptomic profiling technologies has been used to systemically dissect the genetic mechanisms of stress responses in Arabidopsis in recent years.
Recently, high-throughput sequencing has been used to systemically identify plant miRNAs responsive to abiotic stress in several plant species, and this has greatly advanced our knowledge of the miRNAs functions in stress tolerance [ 36, 37, 50].
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For nonviral vehicles, a liposomal delivery system, YSK05-MEND, was used to systemically administer anti-miRNA oligonucleotides (AMOs) to the livers of mice at a low dose [ 70].
Transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic mechanical thermal analysis (DMTA) and tensile tests were used to systemically characterize the high performance composite films.
To evaluate the role of endogenous TGF-β signaling in vivo, adenovirus of Ad-sEng was used to systemically inhibit TGF-β signaling in mice; control mice included non-infected mice (Figure 1B) and mice infected with an Ad-null virus (Figure 1C).
Osteoblastic cell line ROS17/2.8 was used to systemically investigate the impact of substrate signals on cellular responses.
Several viral-mediated delivery approaches can be used to systemically target the liver with a gene of interest.
In this study, we demonstrate that the immunosuppressive role of MSCs might be of therapeutic value in CIA, and that MSCs may be used to systemically express anti-inflammatory cytokines.
Sodium 2,3-dimercapto-1-propane sulfonate (DMPS, Dimaval) is a water-soluble chelating agent that can be given by mouth or systemically and has been used to treat metal intoxication since the 1960s in the former Soviet Union and since 1978 in Germany.
Manganese-enhanced MRI (MEMRI) with systemically administered MnCl2 has been used to examine neuronal activity in vivo [18], [19], [20].
Experimental administration of Zymosan, both systemically and intratracheally, has been used to induce neutrophil infiltration and develop pulmonary inflammation in animal models [ 17, 18].
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