Botox had been used off-label for cosmetic purposes prior to this.
Selective serotonin reuptake inhibitors (SSRIs) have been used off-label for PE, with varied results.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) (INFUSE, Medtronic, Memphis, TN, USA) has been used off-label for posterolateral lumbar fusions for many years.
The technology is seen as a safer alternative to prescription drugs, such as modafinil and ritalin, both of which have been used off-label as performance enhancing drugs in the armed forces.
He also noted that although ketamine has been available for decades and has been used off-label to treat depression, he hasn't encountered people who now use the drug recreationally in his research and interviews with illicit drug users.
Lucentis is the Food and Drug Administration-approved treatment for wet A.M.D., whereas Avastin, which is F.D.A.-approved for treating certain cancers, has been used "off-label" to treat wet A.M.D. The final results of the "head-to-head" clinical trial of Lucentis vs. Avastin (the CATT study financed by the National Eye Institute) remain to be seen.
High-dose FVIIa has also been used off-label to manage hemorrhage in trauma and surgical patients, many of whom also develop hypothermia and acidosis.
For decades, antiepileptic drugs (e.g., topiramate, divalproex sodium), antihypertensive agents (e.g., beta blockers, calcium channel blockers, angiotensin-converting enzyme [ACE] inhibitors, aldosterone receptor blockers) and tricyclic antidepressants (e.g., amitriptyline, nortriptyline) have been used "off-label" in CM prevention.
