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ME-7 and RML strains are the two principal mouse inocula, which have been used in mouse scrapie models.
Lifeact peptide fused to FITC has subsequently been used in mouse oocytes to elucidate a novel actin-based mechanism for chromosomal motility [32].
The environmental mycobacterium, M. vaccae has been used in mouse models to support the contemporary hygiene hypothesis that non-pathogenic microorganisms reduce allergy associated T helper (Th 2 responses and inflammatory diseases by augmenting regulatory T cells.
Transplantation has also been used in mouse models of enteric infections.
Activation tagging has been used in mouse somatic models to identify oncogenes [ 20, 21].
MitoQ has been used in mouse models of disorders associated with secondary mitochondrial dysfunction including Parkinson's and Alzheimer's diseases but has not been used in primary mitochondrial diseases.
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C3d has since been used in mice for a variety of vaccine applications including HIV, measles, S. pneumoniae and influenza [17], [18], [19], [20], [21], [22].
Intrauterine infusion of bacteria or their pathogen-associated molecules (PAMPs) such as lipopolysaccharide, have been used in mice to model PID [4], and in pregnant mice to mimic preterm labour [5].
Recently, MR spectroscopy has been used in mice to examine myocardial energy metabolism [ 27, 43].
A DNA vaccine that elicits expression of WNV E and prM antigens has been used in mice, horses, and birds (44).
Facial expression of pain and kinematic and force platform gait analysis have been used in mice and in horses and dogs, respectively [ 54- 56].
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