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A performing art, it has always been uniquely difficult to preserve and reproduce (the tragedy of its impermanence was brought home this summer by the deaths of Pina Bausch and Merce Cunningham).
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Though far from the most common form of cancer, brain cancers are uniquely difficult to treat.
Figures like him are uniquely difficult to get your head — and ears — around.
The result is Doctor Horrible's Sing-A-Long Blog - found at drhorrible.com - and it has been an instant summer success that is uniquely difficult to categorise.
But it makes a strong case that this group of black men with Mohawks, who slam-danced and sang about racism and politics, was uniquely difficult to classify, which made them difficult to promote.
The simple answer is that we don't yet understand the fundamental cause of most psychiatric disorders, in part because the brain is uniquely difficult to study; you can't just biopsy the brain and analyze it.
Mrs Clinton's running mate Tim Kaine paid tribute to her as "a history maker" and said that it was "uniquely difficult" to be elected to federal office as a woman in the US.
Your education has been uniquely difficult – how were you able to find time to study?
In a career that has seen deadly natural disasters, multiple crime scenes and a 2007 stint in Manila working the same 9 p.m. to 5 a.m. shift, the past few months have been uniquely difficult.
Of course my education has been uniquely difficult – no one apart from Chickenshed believed that I was anything more than the label "cerebral palsy" – I was even described to my family as a vegetable.
Legislation (at least UK legislation) is uniquely difficult content to work with.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com