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Neoadjuvant chemoradiation (nCRT) is associated with higher pathologic complete response (pCR) relative to chemotherapy (nCTX), but has not been shown to improve survival; however, previous studies have been underpowered to demonstrate a survival difference.
One study, involving subjects aged ≥60 years, did not find an association between non-migraine headache and ischemic stroke; however, the number of included subjects in this study was low and it may have been underpowered to demonstrate a significant association [129].
Therefore, the study may have been underpowered to demonstrate a significant effect of aspirin on the primary end point.
Upon exclusion of subjects with osteophytes, we may have been underpowered to demonstrate an association between BMLs and BMI.
Moreover, all individual studies published so far have been underpowered to demonstrate effects of CHX-SOD on patient survival.
Our study was powered to look for stage migration, and may have been underpowered to demonstrate differences in timeliness intervals.
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Our study may be underpowered to demonstrate a small effect.
Finally, it is likely that the two studies were underpowered to demonstrate a difference in the principal endpoint.
The sample size was estimated based on the primary clinical outcome, and it is possible that it was underpowered to demonstrate a significant difference in cost-effectiveness.
But this trial was underpowered to demonstrate a significant effect on stroke and only followed patient outcomes for 11 days.
Given the existing data the study may be underpowered to demonstrate small associations, which are not entirely unlikely given the existing results of genome-wide association studies.
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been intended to demonstrate
been underpowered to examine
been discussed to demonstrate
been collected to demonstrate
been underpowered to show
been underpowered to observe
been conducted to demonstrate
been selected to demonstrate
been asked to demonstrate
been made to demonstrate
been solved to demonstrate
been urged to demonstrate
been invited to demonstrate
been presented to demonstrate
been underpowered to reliably
been underpowered to find
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com