Sentence examples for been under strong evolutionary from inspiring English sources

Because their normal function in depolarizing excitable membranes requires only a few channels per square micron of membrane, VGSCs have been under strong evolutionary pressure to maintain expression levels at an appropriate and stably regulated low level.

Once the UGA motif was established in late branching chlorophytes, it seems to have been under strong evolutionary pressure, as it has changed so little in the various chlorophyte lineages (compare the observed variation in streptophytes).

As the major physiological process that provides plants with carbon and energy, photosynthesis is under strong evolutionary selection that gives rise to variability in nearly all parts of the photosynthetic apparatus.

The prediction of [27], [28] is that those sequences falling on the scaling curve from genomic alignments are under strong evolutionary constraint; however, their functions – if not miRNAs - are most likely novel, presenting an intangible experimental challenge.

These observations suggest that MblC is under strong evolutionary pressure since it has not changed significantly over at least 13 million years (almost 100% protein identity in melanogaster group species) and can be found in Nematoda.

Because the viral and prokaryotic genomes were under strong evolutionary pressure to minimize genome size, overlapping genes represent an excellent strategy to condense a maximum amount of information into short nucleotide sequences [20].

We demonstrate a striking shift in the thermal response properties of X. laevis TRPM8 compared to its mammalian and avian counterparts, supporting the notion that the properties of temperature-sensitive TRP channels are under strong evolutionary pressure to conform to a physiologically relevant temperature range.

This conclusion is in line with the expectation that contact residues are in general much more likely to be under strong evolutionary constraint compared with noncontact residues.

Cis-regulatory elements can be predicted by sequence conservation analysis, as tight clusters of functional TFBSs can be under strong evolutionary constraint [ 4- 7].

DNA repair may thus provide biological systems with the possibility to insert potential regulatory elements within encoding sequences as well as the means to remove them (fig. 3 D), even in a very precise manner, from genes that are under strong evolutionary pressure.

On the other hand, the likely enrichment of recent positive selections at the subcentral positions can be explained: Genes with protein products of very high centrality could be under strong evolutionary constraints and hence accommodate fewer selective events, whereas genes at the periphery may not contribute strongly enough to phenotypic effects for selection due to their network locations.