Sentence examples for been under selective constraint from inspiring English sources
Lin et al. also found that the regions from the TSS to −200 bp show fewer deletion polymorphisms among S. cerevisiae strains than expected, suggesting that the distance between TSS and TFBS has been under selective constraint.
This is likely to be a conservative test for purifying selection because many synonymous sites are under selective constraint in S. cerevisiae (Zhou et al. 2010), and intergenic regions are likely to contain constrained sequences other than TFBSs (e.g., nucleosome positioning elements, noncoding RNAs etc).
Andolfatto (2005) has concluded that non-coding regions of Drosophila are under selective constraint and also subject to bouts of adaptive selection.
If the dN/dS rate ratio is <1, there is evidence for purifying (negative) selection, and the duplicated genes are thought to be under selective constraint.
The presence of conserved non-coding nucleotide stretches implies that a region is under selective constraint and therefore is likely to perform an important function.
The underlying assumption is that an accurate prediction algorithm should identify functionally important sites that are likely to be under selective constraint.
A substantial fraction of non-coding DNA sequences of multicellular eukaryotes is under selective constraint.
This genomic region is evolutionarily conserved across a range of mammals, suggesting that it is under selective constraint.
The evolutionary path leading up to long introns as well as whether the first intron length is under selective constraint are not known.
