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Dr. Pritchard's team found that several genes associated with embryonic development of the bones had been under selection in East Asians and Europeans, and these could be another sign of the forager-to-farmer transition, Dr. Klein said.
Several genes related to the production of human sperm also have been under selection in the past 10,000 years.
Extreme Rab values would be associated with alleles that have potentially been under selection in one of the two populations.
Recently, with the advent of large, publicly-available data sets, the completion of many mammalian genome sequences, and large-scale genotyping resources, there has been much effort in attempting to identify loci which have potentially been under selection in the entire human species, or locally in specific human populations [1] [11].
Finally, we use long-range haplotype tests to show that OCA2 is or has been under selection in Europe and the derived allele of rs1800414 is, or has been, under selection in East Asia.
Voight et al [ 22] used linkage disequilibrium (LD) estimated by iHS statistic to identify loci which have been under selection in the last 45,000 70,000 years.
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As a result, anti-predator behaviors may not be under selection in cattle, and may actually be selected against (see below).
In order to test if certain codons were under selection in the foreground branches, and thus identify positively selected sites within specific monophyletic lineages in our trees, we also fit the branch-site models.
Figure 6 also illustrates the hypothetical evolutionary changes in tibia length and body mass in a selective breeding scenario where these genetically correlated traits were under selection in the same direction.
Dr. Pritchard's test identified 206 regions of the genome that are under selection in the Yorubans, 185 regions in East Asians and 188 in Europeans.
A more powerful test for positive selection is provided by branch-site models, which test if certain codons are under selection in the foreground branch [19].
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