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Of course, the TLRs have been under evolutionary selection pressure since the origin of innate immune receptors in lower organisms.
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We extracted from our miRNA target predictions [58] the top 1000 target sites with the highest probability of being under evolutionary selection, and an equal number of target sites with the lowest probability of being under evolutionary selection, by choosing for each miRNA having at least one high-probability target site, an equal number of low-probability sites.
Alignments of interspecies genomes combined with other modeling efforts can be used to assess the probability that a certain genomic location is under evolutionary selection, and thus more likely to be a functional binding site.
This was further corroborated by Hansen et al., who showed that DNA shape is under evolutionary selection pressure.
We have identified genes that appear to be under evolutionary selection and those that are sex-specific.
There is strong evidence that genes at critical regulatory nodes in the p53 pathway are under evolutionary selection and that SNPs in the p53 pathway influence human fertility.
Functional non-coding sequences are often assumed to be under evolutionary selection pressure, and thereby conserved relative to the surrounding non-functional sequence.
Polymorphisms that arise independently multiple times are of interest since they may represent genetic changes that are under evolutionary selection because they confer an advantage to the organism.
This eliminated sequences that are unlikely to be under evolutionary selection [ 1, 11] and reduced the dataset to a computationally manageable size.
Positions in the stretch of binding residues most tightly connected with one another thus reflect correlated mutations that are under evolutionary selection and are more likely to be important for nucleic acid binding.
By taking advantage of Nature's grand protein engineering experiment, i.e., the large number of gene fusion events that have occurred throughout evolutionary history, we show that these assembly intermediates are under evolutionary selection.
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