As a consequence, mutant p53 is unable to trigger a p53‐dependent biological response, that is cell cycle arrest and apoptosis.
N9-Substituted iP derivatives remained active in both in vitro bioassays in a broad range of concentrations despite the fact that most of the derivatives were unable to trigger the cytokinin response in CRE1/AHK4 and ZmHK1 receptors.
To this end, DROiD injects copies using the cellular network only when needed: (i) in the beginning, when the Wi-Fi infrastructure is unable to trigger the dissemination, (ii) if the evolution of the dissemination is below some expected pace, and (iii) when the delivery delay is about to expire, in order to guarantee that all destinations receive the data.
In Fas-deficient ΔCS mice, TNFα was unable to trigger the loss of RGCs (Figure 2I).
Of particular, R149Q is unable to trigger intracellular signaling and behaves as a competitive inhibitor [29].
In addition, we found that M6 downregulation driven by other follicular GAL4 lines were unable to trigger female sterility.
Therefore, although GR-21OH-6,19OP - like GR-RU486 complex - is unable to trigger a direct transcriptional response, it has the ability to act indirectly as a monomer.
Although DCL3 can generate 24-nt vsiRNAs in RNA virus-infected plants when DCL2 and DCL4 are dysfunctional, DCL3 is unable to trigger antiviral silencing [21].
Thus, pre-MBT embryos lack checkpoints that halt the cell cycle in response to DNA damage [30], [32] and are unable to trigger cell death.
This figure shows that noise in the expression of the LSMGs or NANOG alone is unable to trigger stochastic transitions to the pluripotent state.
