The comparison of experimental and numerical data illustrates the potential of the engineering modeling approach to overcome drawbacks of current design regulations, which are unable to appropriately predict stiffness properties of dowel connections.
The homeland security official said that the administration had drawn a "bright line" against taking babies from their parents because the government was unable to appropriately care for children that young, but could not immediately provide information about the age cutoff below which they would decline to take a child.
For example, species that are unable to appropriately adjust their flowering time in response to climate change could suffer from a sudden lack of pollinators [22], [35].
It does, however, lead to (severe) stress when also removed as the cell is unable to appropriately cope with the resulting loss of function.
In summary, we postulate that IECs are unable to appropriately response to glafenine-induced ER stress and as a result undergo rapid and but orderly apoptosis.
Many types of cancer, as sporadic lung, cervical, and endometrial cancers, carry LKB1 deficiency that can be exploited with metabolic drugs since these cells are unable to appropriately respond to metabolic stress [ 43].
Indeed, stratification by radiation treatment demonstrated that the association between Bax expression and DSS was most pronounced in patients that received adjuvant radiotherapy (Additional file 3: Figure S3); however, we were unable to appropriately assess this effect in our cohort.
In several studies, after controlling for possible confounding, the association of IPI with adverse outcome became non-significant, but it is possible that studies were unable to appropriately control for confounding given differences between women with shorter versus longer IPIs.
49 In particular, we were unable to appropriately assess the risk of selective outcome reporting bias because none of the selected trials was registered and study protocols were not available, which precluded assessing whether prespecified (primary and secondary) outcomes were reported.
