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This effect could have been triggered by direct prostaglandin receptor stimulation or changes in intracellular lipid mediators.
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The assembly and activation of a mitochondrial channel is triggered by direct interaction with signaling molecules that promote cell death.
Although the precise mechanism is under investigation, these investigators demonstrated that P4-mediated up-regulation of BCRP could be triggered by direct binding of progesterone receptor B to a progesterone response element identified in the BCRP promoter [181].
A large interest has been triggered by the recent direct measurements of cosmic positrons and electrons.
This is triggered by the direct blockade of NMDA receptors.
Thus, it is unlikely that the transcriptome response at late time points was triggered by a direct response to HDACi.
Furthermore, DNA-independent PARP1 activation can be triggered by the direct interaction of PARP1 with phosphorylated ERK-2 without PARP1 being phosphorylated itself [ 52].
Recent data suggested that it might be triggered by the direct action of microorganisms and their products on the heart itself.
Biological control is a complex process which requires the host to be recognised by the biocontrol agent, followed by hydrolytic enzyme and antibiotic production which is triggered by the direct attachment of the mycoparasite to the host fungus.
The TGNs can also inhibit DNA methylation and so promote cytotoxicity (Hogarth et al, 2008) whist cytotoxicity can be triggered by the direct incorporation of drug-derived TGN metabolites into DNA (Tidd & Paterson, 1974; Karran, 2006).
Pain following disc surgery is related to a number of factors that include the inflammatory cascade which is triggered by tissue trauma and direct manipulation of the nerve root.
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