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This seems to have been the major trigger not just for human civilisation, but also for the accumulation of the familiar repertoire of communicable human diseases.
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Hyperlipidemia (HL) with subsequent coronary atherosclerosis is the major trigger of ischemia and hence, myocardial infarction (MI) occurs.
As the IOL seems to be the major trigger of the intraocular inflammation in uveitic eyes, various materials have been tried in the search for the least immunogenic one.
Moreover, it is likely that modification of routinely sleep habits is the major trigger, since increased sleep duration predisposes to Migraine attacks to the same extent as sleep deprivation [3]. 3.
Therefore, it seems that ficolin-3 should be the major trigger and indicator of lectin-complement activation.
These results indicate that ficolin-3 might be the major trigger of lectin-complement activation in diabetic patients.
Although glucose is the major trigger of insulin release and exogenously added insulin was shown to activate PDE3B in pancreatic islets and β-cells, glucose-stimulated activation of PDE3B is most likely not mediated by an insulin-dependent mechanism.
Ca2+ is the major trigger of insulin secretion (8) and is generally believed to underlie stimulation of glucagon release (16– 216.
This result indicates that the fluoroquinolone ophthalmic solutions are the major trigger for the increased expression of these MMPs in the normal corneal epithelium.
A DNA-containing protein complex from Plasmodium falciparum, the causative agent of malaria, is also known to be the major trigger of the innate immune response [ 51].
Dysfunction in ion-channel homeostasis is the major trigger of cardiac arrhythmias, which is a serious complication in most HCM patients.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com