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Many medications have been used to try and alleviate NAS symptoms, but their efficacy has rarely been tested in randomised or even quasi-randomised trials.
Newer fosfamides, with slightly different modes of action, and potentially less toxicity, namely evofosfamide and palifosfamide have recently been tested in randomised phase III clinical trials in STS.
The clinical effects of these therapies are variable and often poorly sustained, and only a few of the management strategies used in paediatric populations have been tested in randomised controlled studies with age-appropriate cohorts.
A range of interventions to prevent postnatal mental health problems, principally 'postnatal depression', have been tested in randomised controlled trials.
Several other strategies have already been tested in randomised controlled trials eg financial incentives, hand signed letters, succinct questionnaires and the use of reminders[ 6, 7, 11].
Although the superiority of radical cystectomy over curatively intended radiotherapy has never been tested in randomised trials, retrospective analyses seem to favour the first (Shelley et al, 2001).
Similar(48)
Continuous hyperfractionated accelerated radiation therapy (CHART), which reduces overall treatment from 6-7 weeks to 12 days and gives 36 small fractions, has now been tested in multicentre randomised controlled clinical trials.
The patient safety program was tested in a cluster randomised trial on ten hospital wards and ten nursing home wards.
The effectiveness of the nine-session group programme TRAMPOLINE for children from substance-affected families will be tested in a multicentre randomised controlled trial.
There were, in all, 20 treatment combinations in each experiment (six wheat/mustard covers plus four rye-grass covers × two ploughing dates), which were tested in four fully randomised blocks.
The effectiveness of this intervention is currently being tested in a pragmatic cluster randomised controlled trial.
More suggestions(15)
been operationalised in randomised
been tested in open
been tested in randomized
been assessed in randomised
been tried in randomised
been shown in randomised
been tested in other
been done in randomised
been studied in randomised
been investigated in randomised
been introduced in randomised
been tested in late-stage
been tested in scientific
been evaluated in randomised
been applied in randomised
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com