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Importantly, miR-122 inhibitor (miravirsen) has been tested in Phase 2a trial in chronic hepatitis C patients (NCT01200420 30 while miR-34 (MRX34) has been tested in Phase 1 trial in liver cancer patients (NCT01829971A 31.
Ferric citrate has been tested in phase 2 trials as a phosphate binder.
This article focuses on clinical treatments for ALI that have been tested in phase II and III clinical trials as well as a discussion of potential future therapies.
It is the first time that a new generation of HIV antibodies has been tested in phase 1 clinical trials.
ITF2357 has been tested in Phase II clinical trial for Hodgkin's lymphoma, chronic myeloproliferative diseases and juvenile idiopathic arthritis, and is currently undergoing evaluation for long-term study on chronic myeloproliferative neoplasm (ClinicalTrials.gov Identifier: NCT01761968).
First generation CARs have been tested in phase I clinical studies in patients with ovarian cancer, renal cancer, lymphoma, and neuroblastoma, where they have induced modest responses.
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So far, class-I and II HDAC inhibitors have been tested in phase-I and II clinical trials.
In addition, multiple other targets for immune-checkpoint blockade therapy, such as lymphocyte-activation gene 3 (Land) and CD276 (B7-H3), are currently being tested in phase I and phase I/II clinical trials involving patients with a variety of malignancies115.
However, because it is thought that creatine will be more effective when used in combination with other drugs, additional research will first determine what other drugs it should be paired with before it is tested in phase III trials.
Three available surfactants named as Petrostep S13A, S3B, and S13C were tested in phase behavior experiments.
The monoclonal antibody TRC105 binds endoglin with high avidity and is currently being tested in phase 1b and phase 2 clinical trials.
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been investigated in phase
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