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Intravitreal dexamethasone is sometimes administered in conjunction with the intravitreal antifungal medication to reduce intraocular inflammation although the efficacy has not been tested in controlled, masked studies [1, 5, 12, 13].
However, the effectiveness of these conditions has never been tested in controlled experiments harboring defined structural features capable of blocking RT activity, therefore supplementary testing will be required before implementing them.
For H1N1 and other influenza viruses, the drug has been tested in controlled trials of prophylaxis and treatment.
Whether this translates into preventing people transmitting malaria to mosquitoes has rarely been tested in controlled trials, but there appeared to be a strong reduction in infectiousness in the two small studies that evaluated this.
At the same time, individual rehabilitation programs derived from assessment of each patient's characteristics and needs, i.e., tailored rehabilitation [ 8], have not yet progressed nor been tested in controlled trials.
However, most of the existing work has been tested in controlled environments and is not robust enough for real-world applications.
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According to SmithKline Beecham, the vaccine was tested in controlled, double-blind clinical trials involving 10,936 people; after two years, those who were vaccinated were not reported to have suffered any more illnesses than those who were not.
Preventive measures and programs are clearly needed and, optimally, should be tested in controlled intervention studies.
The feasibility and effectiveness of these strategies should be tested in controlled trails.
Other issues, such as whether hybridized populations experience a loss of local adaptation to environmental extremes, may be tested in controlled experimental settings.
Beyond its antioxidant properties, the role of melatonin as a systemic immunoregulatory agent sensitive to exogenous regulation is an exciting idea to be tested in controlled trials of human sepsis [ 40].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com