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A large number of agents, including 5-fluorouracil (5-FU), mitomycin-C, and cisplatin, have been tested as single agents or in combination therapies without appreciable efficacy (Hejna et al, 1998; van Riel et al, 1999; Yee et al, 2002).
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The probabilities p i were estimated using trials where the agents were tested as single agents.
Overall, 184 agents were tested as single agents or in combination in the collected trials.
5 New agents such as bevacizumab are being tested as single agent chemotherapy or in combination with other drugs.
This cohort could be, in principle, the union of all cohorts where the drugs were tested as single agents.
The following method was adopted in order to build the SCS: comorbidities were tested as single variables in independent univariate analysis.
On the basis of our results (refs. 23, 24 and this paper) and those recently published by others, we propose HDACi to be tested as single agents in clinical trials dedicated to sensitive AML subtypes such as that expressing AML1/ETO.
In a Phase I trial conducted at the National Cancer Institute, romidepsin was tested as single-agent treatment in four patients with T cell lymphoma (see Table 2).
Radiolabelled somatostatin analogues have been tested as a single therapy for SCLC, but this has not been as promising as predicted, based on preclinical study results [17 19].
Thus, a variety of anti-inflammatory and immunomodulatory agents have been tested as potential single or combination therapies in the management of intraocular inflammation, hyperpermeability, and neovascularization.
Furthermore, to the best of our knowledge, although the powder of M. oleifera seeds has been tested as a single primary coagulant for treating TSW, none has been tested in combination with two-stage filtration process.
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