A series of novel enediyne-containing molecules, 1-aryl-6- 3,4,5-trimethoxyphenyl -3(Z)-hexen-1-aryl-6- 3,4,5-trimethoxyphenyl -3splayed 1-aryl-6- 3,4,5-trimethoxyphenyl -310−6 M 1-aryl-6- 3,4,5-trimethoxyphenyl -3
The most promising non-carboxylate P2 candidate (compound 33RE) was synthesized and displayed potent and N-selective inhibition.
A novel fluorescent probe based 1,8-naphthalimide (NFH) for fluoride naked-eye recognition was synthesized, and it displayed high selectivity and sensitivity.
Isomeric oxo-bridged analogs of aza-trishomocubane sigma receptor ligands were synthesized and shown to display a reduced affinity for the σ receptor.
In contrast, when the linear version KYG-16511) of the best hit from either the C2 or C3 libraries KYG-13511) wasynthesizeded and evaluated, it also displayed reduced affinity relative to its cyclic analogue, but the decrease was much less dramatic (∼3-fold).
Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A2 (sPLA2) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations.
were synthesized and annealed.
It is synthesized and degraded dynamically.
Recently, neomycin- or kanamycin A -cationic lipid conjugates were synthesized that displayed high activity against both MRSA and MRSE, respectively [ 20].
A large number of CUR analogs have thus been synthesized in recent years, and many displayed activities similar to the mother compound [ 12, 13].
