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This suggests that nuclear expression of WTPTEN is necessary for growth regulation and provides a protective effect in the cell, which has been supported in thyroid, breast and pancreatic islet models.
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The clinical impression of euthyroidism is supported by normal serum thyroid stimulating hormone (TSH) in most of these patients [ 1].
A potential role of hypometabolic stages in the pathomechanism of AD is supported by recent data on thyroid disease as a potential risk factor for AD [72].
The majority of cases were characterized by abnormal thyroid function (seven hypothyroidism; two hyperthyroidism), but the diagnosis of thyroiditis was supported by ultrasonography only in half the cases.
The use of galectin-3 radiotracer for detection of thyroid cancer in vivo is supported by a solid molecular rationale [5], [7] [10].
Collectively, our observations provide evidence that DIM inhibits the estrogen mediated increase in thyroid cell migration, adhesion and invasion which was supported by ER-α downregulation studies.
These findings provide further support that S100A4 is involved in thyroid cancer invasion and metastasis.
The risk of thyroid cancer in women increases at the time of puberty and declines after menopause [ 7, 40], supporting the hypothesis that menstrual cycle factors are involved in thyroid carcinogenesis.
Our results support the suggestion that NrCAM is one of the several adhesion molecules that are involved in thyroid carcinogenesis (Brabant et al, 1995).
CD62L was expressed in thyroid lymphocyte infiltrations.
There were changes in thyroid weight, thyroid histopathology, and thyroid hormone levels in the dams or the offspring.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com