Optional semantically validated datasets can also be suggested upon user request.
Search fields, which operate on a defined vocabulary, like the Gene Ontology terms [ 31], have 'auto-suggest' functionality, where possible search terms are suggested upon typing the first letters.
Shortterm use is suggested, upon cautious assessment of patient comorbidities and with close monitoring for gastrointestinal and renal adverse effects as well as for drug to drug interactions.
Finally, it has been suggested that upon transcription arrest 7SK RNA may shuttle between the P-TEFb LC to hnRNPs with a concomitant dissociation of P-TEFb LC [31], [32].
In addition, a genetic interaction between TACC3 and p53 has been suggested, based upon work carried out in mice [ 52].
It has been suggested that upon encounter with trimeric TNF-α, the TNF receptors undergo trimerization, which leads to intracellular signaling [ 6, 7].
It has been suggested that upon the cleavage of the propeptide region, the mature ZP2 protein plays a role in the prevention of polyspermy [ 33].
At least some of this damage is thought to be causal for loss of function during aging, although an intriguing alternative perspective has been suggested, based upon deleterious effects of TOR activity later in life (Blagosklonny, 2010).
It has been suggested that upon DC maturation, the expression of CCR2, along with CCR3, CCR5, and CCR6, is downregulated and CCR7 expression upregulated, a concept sometimes referred to as the chemokine receptor "switch paradigm" (24).
It has been suggested that upon recognition of strong agonist ligands by the TCR, LCK undergoes Ser phosphorylation at position 59, preventing recruitment of SHP1 and subsequent TCR desensitization (Stefanova et al, 2003).
