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Beyond ABCD1, environmental triggers and other genetic factors have been suggested as modifiers of the disease course.
These diagnoses have previously been suggested as modifiers of the cardiovascular effects of particles (Sunyer et al. 2000; Zanobetti et al. 2000b).
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The most clear-cut is modification of BRCA2-associated breast cancer risk by RAD51 [ 25], but other genes, including FGFR2, TNRC9, AURKA, and MAP3K1 [ 26- 28], have been suggested as risk modifiers.
ZNF259 has been suggested as a modifier gene in spinal muscular atrophy [ 40], but no direct link with carcinogenesis has been established thus far.
As the gene has been suggested as a putative modifier of CF severity in humans24, we predicted that increased activity of KCa3.1 might contribute to compensate the failure in anion and fluid secretion leading to meconium ileus.
All studies examine the role of SES, which has been suggested as an effect modifier for the relationship between exposure to the natural environment and health benefits.
We include a measure of social support in the workplace since it has been suggested as an important stress modifier [44].
The heart of cellular reprogramming is epigenetic modifications and it has been suggested that epigenetic modifiers such as TSA have a carryover effect on a wide variety of epigenetic cellular characteristics [ 26].
It has been suggested a modifier effect on the risk that depends on genetic loadings.
In this regard, exosomes have been suggested to function as immune-response modifiers because these vesicles are secreted by many types of tumors cells.
Moreover, essential oils are known to have antimicrobial properties, and have been suggested to act as rumen fermentation modifiers [ 18].
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