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The CRISPR/Cas9 system has been successfully utilised to introduce genetic modifications in a wide range of species, rendering it a powerful tool in genetic engineering.
Bioluminescence imaging has been successfully utilised to study the development of arthritis in transgenic mouse models [61], and because of its high sensitivity, it is also used widely in bone metastasis studies, to monitor the development and progression of luciferase positive tumour cell lines within the whole body [62].
To date, such as approach has been successfully utilised to screen candidate biomarkers for lung cancer and ovarian cancer [ 13, 14].
Consequently, the failure to detect variants should not be attributed to a deficiency in the accuracy of the method, which has been successfully utilised to detect both novel and previously described polymorphisms in a similar context [ 20, 27].
Although ERPs have been successfully utilised to address important questions about encoding, storage, and consolidation processes in the immature brain (e.g. Bauer et al., 2003, 2006), the inability of ERPs to penetrate to many of the episodic memory network structures, such as the hippocampus, renders them of limited use when addressing the above theoretical questions.
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Although cupping was successfully utilised to treat pain and a wide variety of other complaints for thousands of years, it has almost vanished from the therapeutic spectrum of modern medicine, especially in Europe.
Whereas some of the common cancer hotspot mutations have been successfully utilised as targets for therapy, targeted monotherapy often fails to cure the patient due to pre-existing resistant subclones (Diaz et al, 2012).
To help physicians save time taking a patient's sexual history, the use of patient-administered sexual history taking instrument to help screen patients for STI risk has been successfully utilised elsewhere [ 73, 74].
In addition to a strictly biological context, the theoretical evolutionary framework has been successfully utilised for an understanding of cultural dynamics (Cavalli Sforza and Feldman 1981 Cavalli Sforza 2004).
This design requires low space velocities and minimisation of forward mixing, and a multi-bed downflow reactor has been successfully utilised in industry.
Because of their advantageous material properties, such as disposability, simplicity, and rapid responses, SPEs have been successfully utilised for the rapid in situ analysis of environmental pollutants.
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