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This has led to a new paradigm in medicinal chemistry, the "multi-target directed ligand" design strategy, which has already been successfully exploited at both academulti-target directedveligand
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As luciferases do not require post-translational modifications for activity and are not toxic to cells even at high concentrations, these enzymes have been successfully exploited as reporters in a variety of ultrasensitive cell-based assays.
CCMV VLPs can be successfully exploited as scaffold for epitope fusions up to 31 aa at the N- and C-terminus, and at a N-terminal 24 amino acid (aa) deletion mutant (N∆24-CP) of the CP protein.
These vulnerabilities are fully operational, and can be successfully exploited, as demonstrated in our research.
This review provides sample evidence that at least some of the enzymes catalyzing particular steps in biosynthetic pathways of amino acid biosynthesis could be successfully exploited as molecular targets for antifungal agents (Table 1; Fig. 12).
In vitro cultures have been successfully exploited for the production of paclitaxel, an anticancer agent from Taxus species, at industrial scale, and attempts are being made to increase production using elicitors [ 43].
Very few of the facilities have been successfully exploited commercially.
Only with active flight have the resources of the aerial habitat been successfully exploited.
Other minerals that have been worked intermittently include gold, silver, chromite, diatomite, and dolomite, but none has been successfully exploited.
The primary advantage offered by such FPIs is their high resolution, which has been successfully exploited for the spectral characterization of narrow bandwidth sources22.
"Hardware vulnerabilities have been successfully exploited to completely compromise a modern computing system," said Oberg.
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