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Derived from the microbial CRISPR (clustered regularly interspaced short palindromic repeat) type II adaptive immune system, Cas9 has now been successfully engineered for genome editing applications in a variety of animal and plant species.
S. cerevisiae has been successfully engineered for asymmetric reduction of prochiral ketones (Johanson et al. 2005, 2008), kinetic resolution of racemic diketones (Carlquist et al. 2008, 2009) or asymmetric Baeyer-Villiger oxidation of cyclic ketones for the generation of chiral lactones (Kayser et al. 1998; Stewart 2000).
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To address this issue, a cleavable DNA-protein hybrid molecular beacon was successfully engineered for signal amplified FA bioassay, via combining the unique stable structure of molecular beacon and the large molecular mass of streptavidin.
Spontaneously flowing liquids have been successfully engineered from a variety of biological and synthetic self-propelled units1,2,3,4,5,6,7,8,9,10,11.
In addition, allosteric properties have been successfully engineered into proteins for drug design or the development of novel biosensors.
Several Anticalins directed against medically relevant disease targets have been successfully engineered and can be applied, for example, for the blocking of soluble signaling factors or cell surface receptors or for tissue-specific drug targeting.
To their surprise, 99.5 per cent of offspring had been successfully engineered, Professor James said.
Monoclonal antibodies have been successfully engineered as approved therapeutics.
Many protein fragments have been successfully engineered using multiple display platforms.
There have been examples where each of these reasons has been successfully engineered.
In addition, viable whole genome recombinants between different prokaryotes have also been successfully engineered [ 35].
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