IL-18 was initially described as a potent inducer of interferon-γ production and was subsequently realized to be important in T-cell differentiation (30).
The ESCRT machinery was subsequently realized to have a role in exosome biogenesis when it was discovered that syndecan heparan sulfate proteoglycans (one type of cargo packaged into exosomes) interact via a cytoplasmic adaptor protein with ALIX, and exosome budding is blocked upon knocking down expression of ALIX, VPS4, or CHMP4 subunits of the ESCRT-III complex.
Thus, the creation of numerous tiny through-holes across the whole ARLIB body is testified feasible, and a designed breathability catering to the demand of comfortability in wearable devices is subsequently realized.
The second approach considers frequency domain solution of the L-optimal design problem to obtain the optimal discrete spectra of the test signals, which is subsequently realized as a periodic signal.
Although the prognosis of patients with diffuse pulmonary fibrosis is poor, it was subsequently realized that many patients did not have the extremely rapid deteriorating course that was described by Hamman and Rich.
Phenol or its derivatives were introduced as a bacteriostatic agent and preservative in insulin preparations; however, it was subsequently realized that phenol was critical in stabilizing the dimer dimer interactions within the hexamer, thereby protracting the action of insulin [ 76, 88, 89].
Subsequently, solid state NMR spectroscopy has been realized to be the most important means to determine not only microscopic molecular structure but also macroscopic molecular packing.
It was also subsequently realized that NMDA receptors play a central role in the processes of induction and maintenance of pain sensitization, accounting for the analgesic efficacy of ketamine 13.
Partial light can be subsequently reflected to POFP layer, while the light stimulated from POFP will finally cause interference with the reflected light to realize enhancement.
