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The effects of a joint evolution of spikes dynamics, depending on synaptic weights distributions, and synaptic weights evolution depending on spike dynamics have been studied in [61].
Such apparent contradiction with a previous work (41) might be related to the fact that activation of BK is supposed to last for only few tens of milliseconds, but not for the long periods of local acidification used in this work, apart from the absence of a direct link between what was studied in HEK cells and synaptic transmission models like mouse MNTs.
Post-synaptic currents (PSCs) were studied in voltage-clamp mode at −70 mV holding potential.
Modifications of gene expression [ 21] and protein translation [ 22] have been largely studied in synaptic function and plasticity, or in the symptomatology of neuronal diseases [ 23].
For his Ph.D. and postdoctoral work, he has been studying the mechanisms underlying synaptic vesicle cycle in Caenorhabditis elegans neuromuscular junctions and mouse hippocampal neurons.
Synaptic pathology may be studied by examining protein biomarkers specific for different synaptic elements.
While there have been studies involving synaptic plasticity in the ACC in vitro (Sah and Nicoll 1991; Hedberg and Stanton 1995), only a few reports have indicated the plastic properties of the ACC in vivo (Wei and Zhuo 2001; Zhuo 2007).
While there have been studies involving synaptic plasticity in the posterior cingulate cortex (Hedberg and Stanton 1995) and in the ACC in vitro (Sah and Nicoll 1991), only a few reports have examined the plastic properties of the ACC in vivo (Wei and Zhuo 2001; Zhuo 2007).
Arc has been extensively studied in the context of synaptic scaling because its activity-dependent local protein synthesis enhances basal AMPAR endocytosis.
Together, our data indicate that PSD-95 and Gephyrin FingRs can report the localization and amount of endogenous synaptic proteins in living neurons and thus may be used to study changes in synaptic strength in vivo.
Biophysical studies have suggested that glutamate is present in synaptic vesicles at concentrations exceeding 100 mM (2- 4).
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