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Before the Surgical Treatment for Ischemic Heart Failure trial, less than 1000 patients with ischemic cardiomyopathy had been studied in randomized comparisons of medical therapy versus coronary artery bypass grafting.
The economic impact of the use of LMWHs has been studied in randomized controlled studies, in demonstration projects in managed care institutions, and in decision models.
There are now three novel oral anticoagulants, which have been studied in randomized controlled trials and subsequently approved by the Federal Drug Administration for stroke prevention in patients with atrial fibrillation.
The beneficial effect of sUA lowering on cardiovascular mortality has not been studied in randomized controlled trials (RCTs).
Antithrombin (AT) is one of several anticoagulants that have been studied in randomized trials of sepsis without benefit.
Warfarin has not been studied in randomized trials in this population, and trials of low-intensity warfarin for the maintenance of access patency showed no benefit [ 7, 8].
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Surgical removal of CNV in AMD has been studied in a randomized, controlled trial and was found not to be better than observation alone with regards to maintenance of vision (SST 2004a, 2004b).
However, the efficacy and safety of VTE prophylaxis in thermally injured patients continue to be elusive as it has never been studied in a prospective, randomized fashion.
The Science Teachers Learning from Lesson Analysis (STeLLA) PD program is one of a handful of programs that has been studied in a cluster randomized experimental study where the program was compared with another PD program of equal duration and where analysis included impact on teaching practice and student learning.
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer.
Thrombolytic therapy and surgical removal of hematomas is another technique that has been studied in a single center randomized clinical trial (Class IIB, Level of Evidence B) [ 143].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com