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This combined treatment mode has been studied in randomised controlled trials [ 43, 44].
To date, only a small number of the various available anti-adhesion agents have been studied in randomised controlled trials.
The efficacy and tolerability of tumour necrosis factor (TNF) blockers have so far been studied in randomised controlled clinical trials (RCTs) and observational studies [ 1- 10].
6 7 10 11 18 19 27 Not all of these risk factors have been studied in randomised controlled trials with disease incidence or mortality end points, and this may never be done for feasibility or ethical reasons.
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Treatments should be studied in randomised controlled studies.
The clinical relevance of bacteria for wheezy episodes should be studied in randomised controlled trials of antibiotic treatment in this setting.
Overdiagnosis can be studied in randomised controlled trials by comparing the cumulative incidence of breast cancer in the intervention and control arms at different times from date of entry or randomisation.
Hospital at home schemes for the treatment of COPD exacerbations specifically, have been studied in several randomised controlled trials [ 18- 25] and various non-randomised studies including observational studies [ 26- 31] and studies with retrospective analysis [ 32].
The ERA bosentan has been studied in a randomised controlled trial in patients with PAH-CHD (the Bosentan Randomized trial of Endothelin Antagonist THErapy (BREATHE -5 trial); 8 however, this study focused on patients with Eisenmenger syndrome.
However, in a previous study we found that nearly one out of two new medicines had been studied in a randomised active control trial [ 8].
Exercise, however, as a treatment for OA has been studied in numerous randomised controlled trials, mostly in people with OA of the knee.
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