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Time temperature indicators have been studied historically as an important issue for ensuring the potency of life-saving vaccines around the world.
It has been studied historically in the context of inter-state wars [42], [43] and more recently for terrorism [1] and intra-state conflict [2], [3].
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Mining impacts on stream systems have historically been studied over small spatial scales, yet investigations over large areas may be useful for characterizing mining as a regional source of stress to stream fishes.
Cellular (or "cytotoxic") edema is strongly linked to brain excitability, which has historically been studied in the context of seizure (Schwartzkroin et al., 1998).
Although DNA methylation has historically been studied in the context of gene repression, recent studies have identified other potential roles of DNA methylation in regulating intergenic/cryptic start sites, splicing and as a biomarker of histone modifications and transcription factor binding (reviewed in Ref. 44).
To the extent that hormone levels among women in our extreme categories of westernisation reflect those of the Asian and Caucasian women that have historically been studied, the small number – 15 and 26 women in the least and most westernised groups, respectively – provided limited power to explore possible differences between them.
"Historically, drugs have been studied by themselves.
Historically, POPs have been studied for their ability to cause adverse effects, including liver toxicity (Lee et al. 2014).
Other metrics that have been used to study LBP care including psychosocial factors such as depression and "global effect" (Chapman et al. 2011)—were excluded from the set, as historically they have been studied with inconsistent definitions (Chapman et al. 2011) and they are probably reflected in other domains such as HRQOL.
Historically, the associations between metabolic abnormalities and cardiovascular disease have been studied largely during fasting conditions.
Historically female primates were studied only in their interactions with males or with infants.
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