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For example, chronic stress has been speculated to lead to parafunctional activities such as repetitive tooth clenching or grinding that then produces strain injury to masticatory muscles leading to pain [4 6], although the relationship between bruxism and craniofacial pain may be more complex [7, 8].
This has been speculated to lead to reduced resistance to parasites and, possibly, increased susceptibility to novel parasites (76).
Tubal abnormalities and dysfunction, such as altered contractility or abnormal ciliary activity, have been speculated to lead to tubal ectopic pregnancy.
The use of technology has been speculated to lead to new evolving patient-driven healthcare models, where the information available will not only empower the patients in being more engaged on their conditions, as our participants also revealed, but will also influence how clinicians deliver treatment and use the information collected to make new recommendations.
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FMRP deficiency is speculated to lead to increased neuronal excitability and susceptibility to seizures in humans.
Polar auxin transport is increased in max2 plants which could be speculated to lead to downregulation of SA-responses similarly to BUD1 mutant [ 74].
It is believed to be induced by chronic placental hemorrhage, and is speculated to lead to fetal lung injury when the fetus aspirates the amniotic fluid contaminated with blood [ 10].
It has been speculated that scar formation leads to tape shortening and stiffening.
Thyroid hormones have been shown to influence the maturation and specialisation of the taste buds [132], and it has been speculated that hypothyroidism could therefore lead to a reduction in taste.
The biological mechanisms that underlie this remain unclear, although in the setting of inflammatory signalling pathways it has been speculated that homozygote states may lead to extremes of inflammatory response that, under certain circumstances, are detrimental to the host, whereas heterozygosity may result in intermediate signalling that leads to an optimal inflammatory response [ 31].
Furthermore, it has been speculated that brain atrophy may lead to inappropriate brain re-expansion postoperatively and thereby create the potential for re-accumulation of the haematoma [ 4, 16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com