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The two mammalian Cdc14 isoforms have been speculated to exert essential mitotic functions, given the role of budding yeast ScCdc14 played in the cell cycle and the fact that both human CDC14A and CDC14B could rescue the mitotic exit defects of ScCdc14 mutants [ 2, 3].
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Disulfide bond formation is speculated to exert considerable effects on residues within the kinase domain, most notably within the active-site cleft.
The relaxin that is found in the circulation could be speculated to exert such effects, but the concentrations are lower than are effective at any known signalling mechanism for the peptide (Sherwood, 2004; Gedikli et al, 2009).
In relation to atherosclerosis, IL-33 is speculated to exert an anti-atherosclerotic effect by inducing a Th1-to-Th2 immune response [ 13], arresting foam cell formation [ 14], stimulating IL-5 production and oxidized low-density lipoprotein antibodies [ 15].
Since skelemin is a family member of myosin-associated myomesin, it was previously speculated to exert a contractile force by linking integrin to myosin.
This thin layer was speculated to be natural tungsten oxide.
Since the methylation activity exists only when both MT-A and MT-B complexes are present, it has been speculated that METTL3 exert its methylation activity with the assistance of additional factors.
It has been speculated that massage may exert a therapeutic effect by reducing tissue stiffness through viscoelastic mechanisms.
An infectious cause of multiple sclerosis (MS) has been speculated, though the potential for gastrointestinal pathogens to exert neurological effects remotely (as seen with many Clostridium species) has not been considered likely.
While evidence of virus escape implies NAb selective pressure to a certain extent [10], [12] [13], it has been speculated that post-infection NAbs could exert only a limited suppressive effect on primary HIV replication [14] [16].
Taking together these findings, it is speculated that YM529 exerts its anti-proliferative effect against NSCLC by induction of cellular apoptosis through the small GTP-binding proteins associated signal transduction pathway.
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