Its contribution to bacterial virulence was proven in uropathogenic E. coli[ 34] and the heme scavenging function of the hemin receptor ChuA is speculated to depend on the activity of α-hemolysin, which gains access to the intracellular heme reservoir [ 35].
Although offshore tsunami deposits were speculated to be more common than onshore deposits (Dawson and Stewart, 2007), their actual deposition and subsequent preservation depends strongly on the local geomorpholog-ical configurations of the shelf and nearshore area and onshore conditions.
A rationale is provided wherein chemical resistance is speculated to be operative.
The emulsification seems to be therefore time dependent [ 11] and it has been speculated that it depends on a combination of the saccadic motion, the difference in density of intraocular fluids and silicone oil, and the gradual decrease of interfacial surface tension of the oil due to the adsorption of surface-active components from the intraocular fluids [ 3, 8, 9].
In this respect, it can be speculated that depending on the epigenetic state of chromatin in the target locus, different functional domains fused to ZFs may exhibit various efficacies.
It may be speculated that such results depend on additional factors such as therapeutic area, patient age or education level, number of medications or general healthcare context.
More than seventy years ago, it was speculated that antibody binding depends on unfolded rather than structured protein [ 1, 2].
It can be speculated that maintenance of CSCs depends upon a specific stem cell niche microenvironment that protects CSCs from therapeutics.
